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/* |
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* RegionAlterations.java |
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* |
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* Created on May 19, 2003, 6:17 PM |
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*/ |
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package org.tigr.microarray.mev.cgh.CGHAlgorithms.NumberOfAlterations.RegionAlterations; |
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import java.util.Collections; |
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import java.util.Iterator; |
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import java.util.Vector; |
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import javax.swing.tree.DefaultMutableTreeNode; |
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import org.tigr.microarray.mev.ISlideData; |
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import org.tigr.microarray.mev.MultipleArrayData; |
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import org.tigr.microarray.mev.cgh.CGHAlgorithms.NumberOfAlterations.NumberOfAlterationsCalculator; |
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import org.tigr.microarray.mev.cgh.CGHDataObj.AlterationRegion; |
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import org.tigr.microarray.mev.cgh.CGHDataObj.AlterationRegions; |
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import org.tigr.microarray.mev.cgh.CGHDataObj.AlterationRegionsComparator; |
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import org.tigr.microarray.mev.cgh.CGHDataObj.FlankingRegion; |
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import org.tigr.microarray.mev.cluster.algorithm.AbortException; |
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import org.tigr.microarray.mev.cluster.algorithm.AlgorithmException; |
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import org.tigr.microarray.mev.cluster.gui.IFramework; |
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/** |
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* |
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* @author Adam Margolin |
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* @author Raktim Sinha |
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*/ |
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public abstract class RegionAlterations extends NumberOfAlterationsCalculator{ |
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|
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/** Creates a new instance of RegionAlterations */ |
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public RegionAlterations() { |
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} |
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|
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/** This method should return a tree with calculation results or |
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* null, if analysis start was canceled. |
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* |
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* @param framework the reference to <code>IFramework</code> implementation, |
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* which is used to obtain an initial analysis data and parameters. |
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* @throws AlgorithmException if calculation was failed. |
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* @throws AbortException if calculation was canceled. |
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* @see IFramework |
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*/ |
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public DefaultMutableTreeNode execute(IFramework framework) throws AlgorithmException { |
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this.framework = framework; |
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MultipleArrayData data = (MultipleArrayData)framework.getData(); |
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Vector allAlterationRegions = new Vector(); |
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for(int chromIndex = 0; chromIndex < data.getNumChromosomes(); chromIndex++){ |
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AlterationRegions curAlterationRegions = new AlterationRegions(chromIndex); |
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Vector curFlankingRegions = new Vector(data.getFeaturesCount()); |
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Iterator featuresIt = data.getFeaturesList().iterator(); |
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while(featuresIt.hasNext()){ |
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Vector curFrs = ((ISlideData)featuresIt.next()).getFlankingRegions()[chromIndex]; |
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curFlankingRegions.add( curFrs.clone() ); |
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} |
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int[] indices = new int[data.getFeaturesCount()]; |
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for(int i = 0; i < data.getFeaturesCount(); i++){ |
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indices[i] = 0; |
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} |
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boolean more = true; |
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while(more){ |
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for(int i = 0; i < indices.length; i++){ |
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Vector expRegions = (Vector) curFlankingRegions.get(i); |
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while(indices[i] < expRegions.size() && ((FlankingRegion)expRegions.get(indices[i])).getType() != getFlankingRegionType() ){ |
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indices[i] += 1; |
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} |
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} |
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int minStartIndex = getMinStartIndex(curFlankingRegions, indices); |
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int minEndIndex = getMinEndIndex(curFlankingRegions, indices, minStartIndex); |
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for(int i = 0; i < indices.length; i++){ |
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Vector expRegions = (Vector) curFlankingRegions.get(i); |
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if(indices[i] < expRegions.size()){ |
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FlankingRegion fr = (FlankingRegion) expRegions.get(indices[i]); |
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int start = fr.getStart(); |
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int stop = fr.getStop(); |
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if(start == minStartIndex){ |
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AlterationRegion curAlterationRegion = curAlterationRegions.getAlterationRegion(minStartIndex, minEndIndex, getFlankingRegionType(), data.getFeaturesCount()); |
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curAlterationRegion.incrementAlterations(); |
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curAlterationRegion.getAlteredExperiments().add(new Integer(i)); |
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if(stop == minEndIndex){ |
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indices[i] += 1; |
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}else{ |
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FlankingRegion tmp = new FlankingRegion(minEndIndex, fr.getStop(), |
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getFlankingRegionType(), chromIndex); |
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expRegions.set(indices[i], tmp); |
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} |
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} |
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} |
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} |
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more = false; |
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for(int i = 0; i < indices.length; i++){ |
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Vector expRegions = (Vector) curFlankingRegions.get(i); |
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if(indices[i] < expRegions.size()){ |
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more = true; |
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} |
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} |
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} |
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allAlterationRegions.addAll(curAlterationRegions.getAlterationRegions()); |
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} |
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Collections.sort(allAlterationRegions, new AlterationRegionsComparator()); |
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return createResultsTree(allAlterationRegions); |
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} |
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private int getMinStartIndex(Vector flankingRegions, int[] indices){ |
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int min = Integer.MAX_VALUE; |
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for(int i = 0; i < indices.length; i++){ |
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Vector expRegions = (Vector) flankingRegions.get(i); |
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if(indices[i] < expRegions.size()){ |
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min = Math.min(min, ((FlankingRegion) expRegions.get(indices[i])).getStart()); |
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} |
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} |
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return min; |
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} |
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private int getMinEndIndex(Vector flankingRegions, int[] indices, int minStartIndex) { |
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int min = Integer.MAX_VALUE; |
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for(int i = 0; i < indices.length; i++){ |
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Vector expRegions = (Vector) flankingRegions.get(i); |
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if(indices[i] < expRegions.size()){ |
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int start = ((FlankingRegion) expRegions.get(indices[i])).getStart(); |
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if(start == minStartIndex){ |
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start = ((FlankingRegion) expRegions.get(indices[i])).getStop(); |
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} |
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min = Math.min(min, start); |
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} |
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} |
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return min; |
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} |
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public abstract int getFlankingRegionType(); |
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} |