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<body bgcolor = "#FFFFCC"><basefont face = "Arial"> |
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<h1>Diversity Ranking Cluster Selection</h1> |
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<hr size = 10> |
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Diversity Ranking cluster selection is an algorithm used to rank a set of clusters |
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based on diversity and then select candidate clusters meeting supplied criteria. |
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This process will tend to find clusters that meet a minimum size and have relatively |
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lower variability between the expression vectors contained in the cluster. This process |
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will find the least variable clusters but there is no means to know if the clusters |
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found will have interesting expression changes over the set of observations. |
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<br><br> |
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Note: See Centroid Variability or Entropy Ranking cluster selection for methods that try |
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to select clusters that have maximal centroid variance over the observations. In some cases |
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it might be advisable to try several selection methods on an input set of clusters. |
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<h1>Parameters</h1> |
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<h2>Desired Number of Clusters</h2> |
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This parameter indicates the number of clusters that should be selected from the input set. |
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If during execution it turns out that the number of input clusters is smaller than the |
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number of clusters desired, then all input clusters are returned as the result. |
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<h2>Minimum Cluster Population (# of elements)</h2> |
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The minimum cluster size describes the minimum number of genes or experiments that should |
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be in the cluster. In some cases clusters may have low variability but are only composed of |
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a couple of elements. |
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<h2>Rank Clusters on Centroid Based Diversity</h2> |
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Centroid based diversity is the mean distance between a each element in the cluster and the |
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cluster's centroid (mean expression pattern for the cluster). (Distance metric is determined |
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by the current global metric defined in the 'Distance' menu. Euclidean is the default metric.) |
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<h2>Rank Clusters on Intra-gene Based Diversity</h2> |
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Intra-gene based diversity is the mean distance between each element in the cluster to |
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every other gene in the cluster. (Distance metric is determined |
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by the current global metric defined in the 'Distance' menu. Euclidean is the default metric.) |
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<br><br> |
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</basefont> |
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</body> |
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</html> |