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<body bgcolor = "#FFFFCC"><basefont face = "Arial"> |
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<h1>HCL: Hierarchical Clustering</h1><h2>Parameter Information</h2> |
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<hr size = 10> |
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<h2> Tree Selection </h2> |
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These checkboxes are used to indicate whether to construct trees for |
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genes, samples, or both. |
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<br> |
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<h2> Distance Metric Selection </h2> |
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This area allows the selection of the metric to be used to assess gene-to-gene |
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or sample-to-sample distances. The initial metric displayed (choosen) corresponds to the global |
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setting in the Multiple Array Viewer's 'Metrics' menu. Alterations to the |
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chosen metric in this dialog will only alter the metric used for the current |
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algorithm run. The global setting in the main 'Metrics' menu will remain unchanged. |
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<br><br> |
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Euclidean Distance and Pearson Correllation tend to be the most frequently used options. |
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An appendix in the MeV manual describes the distance metrics offered in MeV. |
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<br> |
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|
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<h2> Linkage Method Selection </h2> |
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This parameter is used to indicate the convention |
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used for determining cluster-to-cluster distances |
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when constructing the hierarchical tree. Just as distance metrics define |
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gene-to-gene or sample-to-sample distances the Linkage methods |
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are employed to determine cluster-to-cluster distances. |
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<br><br> |
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Single Linkage: The distances are measured between |
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each member of one cluster each member of the other |
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cluster. The minimum of these distances is considered |
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the cluster-to-cluster distance. |
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<br><br> |
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Average Linkage: The average distance of each member of |
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one cluster to each member of the other cluster is used |
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as a measure of cluster-to-cluster distance. |
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<br><br> |
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Complete Linkage: The distances are measured between |
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each member of one cluster each member of the other |
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cluster. The maximum of these distances is considered |
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the cluster-to-cluster distance. |
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<br> |
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</basefont> |
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</body> |
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</html> |