2 |
26 Feb 07 |
jari |
1 |
<html> |
2 |
26 Feb 07 |
jari |
2 |
<body bgcolor = "#FFFFCC"><basefont face = "Arial" padding=10> |
2 |
26 Feb 07 |
jari |
3 |
<h1>USC: Uncorrelated Shrunken Centroids</h1> |
2 |
26 Feb 07 |
jari |
4 |
<h1>Initialization Dialog</h1> |
2 |
26 Feb 07 |
jari |
5 |
<hr size = 1> |
2 |
26 Feb 07 |
jari |
6 |
|
2 |
26 Feb 07 |
jari |
7 |
<h2> Enter all Class Labels </h2> |
2 |
26 Feb 07 |
jari |
8 |
Enter the labels for each of the classes that are in your training set. If there are more than 2 classes, |
2 |
26 Feb 07 |
jari |
9 |
click the Up Arrow of the '# of Classes' spinner. Be advised that you should be entering each and every |
2 |
26 Feb 07 |
jari |
10 |
unique class label here. You will be asked later to assign these labels to your known training hybs. |
2 |
26 Feb 07 |
jari |
11 |
<br> |
2 |
26 Feb 07 |
jari |
12 |
|
2 |
26 Feb 07 |
jari |
13 |
<h2>Analysis Options</h2> |
2 |
26 Feb 07 |
jari |
14 |
The USC algorithm works performing through two main processes - training and classification. |
2 |
26 Feb 07 |
jari |
15 |
One can elect to perform training (with the built in option of classification afterwords) or classification only. |
2 |
26 Feb 07 |
jari |
16 |
<br><br> |
2 |
26 Feb 07 |
jari |
17 |
The 'Training & Classify' option results in specific 'Delta' and 'Rho' values along with 'Training Ratios' |
2 |
26 Feb 07 |
jari |
18 |
which can stored as a file and used for classification at a later time. |
2 |
26 Feb 07 |
jari |
19 |
<br><br> |
2 |
26 Feb 07 |
jari |
20 |
The 'Classification Only' option takes a file input of ratios, delta and rho generated from training and |
2 |
26 Feb 07 |
jari |
21 |
results in a classification of the elements. |
2 |
26 Feb 07 |
jari |
22 |
<br><br> |
2 |
26 Feb 07 |
jari |
23 |
|
2 |
26 Feb 07 |
jari |
24 |
<h2> Advanced Parameters </h2> |
2 |
26 Feb 07 |
jari |
25 |
# Folds refers to the # of times one would like 'Random Permutations' to occur during cross validation. |
2 |
26 Feb 07 |
jari |
26 |
For example, if there are 10 training hybs, and # Folds is set to 5, 2 hybs will be removed and used as |
2 |
26 Feb 07 |
jari |
27 |
the 'test subset' during each Fold. After 5 folds, all 10 hybs will have been removed and used in the |
2 |
26 Feb 07 |
jari |
28 |
'test subset' once. |
2 |
26 Feb 07 |
jari |
29 |
<br><br> |
2 |
26 Feb 07 |
jari |
30 |
#CV Runs is how many times one would like to run cross validation. |
2 |
26 Feb 07 |
jari |
31 |
<br><br> |
2 |
26 Feb 07 |
jari |
32 |
# Bins is the # of Delta values that one would like to try during cross validation. For example, if 'Max Delta' |
2 |
26 Feb 07 |
jari |
33 |
is 20 and '# Bins' is 50, the Delta values would range from 0 - 20 by increments of 0.4 (20 / 50 = 0.4). |
2 |
26 Feb 07 |
jari |
34 |
Delta = { 0, 0.4, 0.8, 1.2... 20 }. |
2 |
26 Feb 07 |
jari |
35 |
<br><br> |
2 |
26 Feb 07 |
jari |
36 |
Max Delta is the maximum Delta (Shrinkage) value to use during cross validation. |
2 |
26 Feb 07 |
jari |
37 |
<br><br> |
2 |
26 Feb 07 |
jari |
38 |
Corr Low and Corr High are the minimum and maximum values one would like to try as a Correlation Threshold value. |
2 |
26 Feb 07 |
jari |
39 |
When the correlation between 2 genes is greater than this value, 1 of the genes will |
2 |
26 Feb 07 |
jari |
40 |
be removed from analysis. |
2 |
26 Feb 07 |
jari |
41 |
<br><br> |
2 |
26 Feb 07 |
jari |
42 |
Corr Step is the increment by which one would like to step between 'Corr Low' and 'Corr High'. By default, |
2 |
26 Feb 07 |
jari |
43 |
cross validation will occur using the set Correlation Threshold = { 0.5, 0.6, 0.7, 0.8, 0.9, 1.0 }. |
2 |
26 Feb 07 |
jari |
44 |
<br> |
2 |
26 Feb 07 |
jari |
45 |
</basefont> |
2 |
26 Feb 07 |
jari |
46 |
</body> |
2 |
26 Feb 07 |
jari |
47 |
</html> |