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package net.sf.basedb.reggie.vcf; |
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import java.util.Comparator; |
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|
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import org.json.simple.JSONObject; |
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|
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import net.sf.basedb.core.DbControl; |
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import net.sf.basedb.core.DerivedBioAssay; |
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import net.sf.basedb.core.ItemSubtype; |
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import net.sf.basedb.reggie.dao.Annotationtype; |
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import net.sf.basedb.reggie.dao.Pipeline; |
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|
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/** |
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For keeping track of warnings. |
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@author nicklas |
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@since 4.14 |
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*/ |
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public class GenoTypeMessage |
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{ |
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|
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/** |
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Comparator implementation for sorting messages by category and name of alignment. |
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@since 4.18 |
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*/ |
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public static final Comparator<GenoTypeMessage> SORT_BY_CATEGORY_AND_ASSAY = new Comparator<GenoTypeMessage>() |
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{ |
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|
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@Override |
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public int compare(GenoTypeMessage o1, GenoTypeMessage o2) |
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{ |
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int order = o1.category.ordinal() - o2.category.ordinal(); |
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if (order == 0 && o1.otherAssay != null && o2.otherAssay != null) |
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{ |
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order = o1.otherAssay.getName().compareTo(o2.otherAssay.getName()); |
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} |
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return order; |
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} |
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|
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}; |
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|
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private static AssayType getAssayType(DbControl dc, DerivedBioAssay assay) |
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{ |
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ItemSubtype subtype = assay.getItemSubtype(); |
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Pipeline pipeline = Pipeline.getByName((String)Annotationtype.PIPELINE.getAnnotationValue(dc, assay)); |
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AssayType assayType = null; |
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if (pipeline == Pipeline.DNA_NORMAL_WGS || pipeline == Pipeline.DNA_GENOTYPING) |
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{ |
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assayType = AssayType.NORMAL; |
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} |
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else |
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{ |
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assayType = AssayType.TUMOR; |
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} |
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return assayType; |
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} |
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|
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private final Category category; |
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private final Level warningLevel; |
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private final String message; |
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private final DerivedBioAssay otherAssay; |
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private final AssayType assayType; |
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private final SpecimenData specimen; |
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private final VcfData vcf; |
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private final boolean flagged; |
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private final VerifiedMatch verified; |
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private final VerifiedMatch currentVerified; |
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private final String doNotUse; |
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private final String doNotUseComment; |
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|
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private String messageTooltip; |
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private String assayTooltip; |
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|
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/** |
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Create a message that is unrelated to another assay. |
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*/ |
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public GenoTypeMessage(Category category, Level warningLevel, String message) |
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{ |
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this(category, warningLevel, message, null, null, null, false, null); |
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} |
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|
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/** |
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Creates a warning thiat is related to another assay. |
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*/ |
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public GenoTypeMessage(Category category, Level warningLevel, String message, DerivedBioAssay otherAssay, SpecimenData specimen, VcfData vcf, boolean flagged, VerifiedMatch verified) |
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{ |
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this.category = category; |
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this.warningLevel = warningLevel; |
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this.message = message; |
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this.otherAssay = otherAssay; |
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this.specimen = specimen; |
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this.vcf = vcf; |
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this.flagged = flagged; |
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this.verified = verified; |
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if (otherAssay != null) |
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{ |
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DbControl dc = otherAssay.getDbControl(); |
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this.currentVerified = VerifiedMatch.getVerifiedMatch(dc, otherAssay); |
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this.doNotUse = (String)Annotationtype.DO_NOT_USE.getAnnotationValue(dc, otherAssay); |
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this.doNotUseComment = (String)Annotationtype.DO_NOT_USE_COMMENT.getAnnotationValue(dc, otherAssay); |
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this.assayType = getAssayType(dc, otherAssay); |
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} |
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else |
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{ |
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this.currentVerified = null; |
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this.doNotUse = null; |
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this.doNotUseComment = null; |
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this.assayType = null; |
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} |
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} |
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|
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public Category getCategory() |
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{ |
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return category; |
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} |
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|
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public Level getWarningLevel() |
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{ |
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return warningLevel; |
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} |
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|
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public String getMessage() |
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{ |
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return message; |
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} |
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|
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public DerivedBioAssay getOtherAssay() |
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{ |
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return otherAssay; |
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} |
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|
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public boolean isFlagged() |
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{ |
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return flagged; |
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} |
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|
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public VerifiedMatch getVerified() |
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{ |
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return currentVerified; |
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} |
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|
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public VerifiedMatch getVerifiedAssay() |
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{ |
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return verified; |
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} |
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|
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public String getDoNotUse() |
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{ |
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return doNotUse; |
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} |
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|
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public String getDoNotUseComment() |
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{ |
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return doNotUseComment; |
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} |
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|
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public void setMessageTooltip(String tooltip) |
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{ |
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this.messageTooltip = tooltip; |
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} |
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|
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public void setAssayTooltip(String tooltip) |
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{ |
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this.assayTooltip = tooltip; |
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} |
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|
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public JSONObject asJSONObject() |
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{ |
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JSONObject json = new JSONObject(); |
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json.put("category", category.name()); |
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json.put("warningLevel", warningLevel.name()); |
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json.put("message", message); |
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json.put("messageTooltip", messageTooltip); |
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if (otherAssay != null) |
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{ |
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json.put("id", otherAssay.getId()); |
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json.put("otherAssay", otherAssay.getName()); |
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if (assayType != null) json.put("assayType", assayType.name()); |
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json.put("assayTooltip", assayTooltip); |
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json.put("flagged", flagged); |
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json.put("verifiedBy", verified == null ? null : verified.name()); |
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json.put("currentVerifiedBy", currentVerified == null ? null : currentVerified.name()); |
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json.put("DO_NOT_USE", doNotUse); |
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json.put("DO_NOT_USE_COMMENT", doNotUseComment); |
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} |
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if (specimen != null) |
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{ |
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json.put("specimen", specimen.asJSONObject()); |
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} |
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if (vcf != null) json.put("vcf", vcf.asJSONObject(false)); |
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return json; |
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} |
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|
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|
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public enum Category |
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{ |
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HIGH_HET(Level.HIGH, "HIGH HET", false), |
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LOW_DATA(Level.LOW, "LOW DATA", false), |
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LOW_GQ(Level.LOW, "LOW GQ", false), |
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LOW_GT_COUNT(Level.HIGH, "LOW GT COUNT", false), |
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VERIFIED_MATCH(Level.INFO, "VERIFIED MATCH", false), |
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GOOD_MATCH(Level.INFO, "GOOD MATCH", false), |
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LOW_MISMATCH(Level.HIGH, "LOW MISMATCH", true), |
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MEDIUM_MISMATCH(Level.LOW, "MEDIUM MISMATCH", true), |
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HIGH_MISMATCH(Level.HIGH, "HIGH MISMATCH", true), |
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DO_NOT_USE_MATCH(Level.HIGH, "DONOTUSE MATCH", false), |
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AMBIGUOUS_PATIENT(Level.HIGH, "AMBIGUOUS PATIENT", true); |
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|
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private final Level defaultLevel; |
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private final String messagePrefix; |
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private final boolean mismatch; |
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|
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private Category(Level defaultLevel, String messagePrefix, boolean mismatch) |
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{ |
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this.defaultLevel = defaultLevel; |
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this.messagePrefix = messagePrefix; |
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this.mismatch = mismatch; |
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} |
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|
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public Level getDefaultLevel() |
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{ |
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return defaultLevel; |
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} |
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|
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public String getMessagePrefix() |
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{ |
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return messagePrefix; |
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} |
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|
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public boolean isMismatch() |
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{ |
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return mismatch; |
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} |
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|
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public GenoTypeMessage message(String info) |
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{ |
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return new GenoTypeMessage(this, defaultLevel, messagePrefix + info); |
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} |
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|
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|
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} |
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|
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public enum Level |
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{ |
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INFO, |
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LOW, |
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HIGH; |
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} |
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|
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public enum AssayType |
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{ |
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TUMOR, |
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NORMAL; |
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} |
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} |