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// $Id$ |
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/* |
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Copyright (C) 2014, 2022 Peter Johansson |
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This file is part of the yat library, http://dev.thep.lu.se/yat |
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The yat library is free software; you can redistribute it and/or |
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modify it under the terms of the GNU General Public License as |
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published by the Free Software Foundation; either version 3 of the |
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License, or (at your option) any later version. |
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The yat library is distributed in the hope that it will be useful, |
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but WITHOUT ANY WARRANTY; without even the implied warranty of |
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MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU |
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General Public License for more details. |
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You should have received a copy of the GNU General Public License |
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along with yat. If not, see <http://www.gnu.org/licenses/>. |
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*/ |
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#include <config.h> |
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#include "SmithWaterman.h" |
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#include "Cigar.h" |
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#include <cassert> |
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namespace theplu { |
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namespace yat { |
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namespace utility { |
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SmithWaterman::SmithWaterman(double gap, double open_gap) |
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: aligner_(gap, open_gap) {} |
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SmithWaterman::SmithWaterman(double vertical_gap, double open_vertical_gap, |
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double horizon_gap, double open_horizon_gap) |
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: aligner_(vertical_gap, open_vertical_gap, horizon_gap, open_horizon_gap) |
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{} |
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const Aligner::Cigar& SmithWaterman::cigar(void) const |
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{ |
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return cigar_; |
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} |
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size_t SmithWaterman::position(void) const |
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{ |
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return position_; |
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} |
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const Matrix& SmithWaterman::score(void) const |
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{ |
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return score_; |
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} |
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double SmithWaterman::operator()(const MatrixBase& dot) |
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{ |
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score_.resize(dot.rows()+1, dot.columns()+1); |
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aligner_(dot, score_); |
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cigar_.clear(); |
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size_t row = 0; |
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size_t column = 0; |
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for (size_t i=0; i<score_.rows(); ++i) |
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for (size_t j=0; j<score_.columns(); ++j) |
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if (score_(i, j) > score_(row, column)) { |
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row = i; |
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column = j; |
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} |
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cigar_.push_front(BAM_CSOFT_CLIP, score_.columns()-column-1); |
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size_t end_row(row); |
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size_t end_column(column); |
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while (aligner_.alignment(row, column)!=Aligner::none) { |
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switch (aligner_.alignment(row, column)) { |
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case(Aligner::diagonal): |
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assert(row); |
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--row; |
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assert(column); |
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--column; |
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if (dot(row, column)>0) |
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cigar_.push_front(BAM_CEQUAL); |
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else |
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cigar_.push_front(BAM_CDIFF); |
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break; |
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case (Aligner::right): |
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assert(column); |
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--column; |
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cigar_.push_front(BAM_CINS); |
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break; |
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case (Aligner::down): |
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assert(row); |
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--row; |
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cigar_.push_front(BAM_CDEL); |
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break; |
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default:; |
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} |
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} |
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position_ = row; |
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cigar_.push_front(BAM_CSOFT_CLIP, column); |
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return score_(end_row, end_column); |
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} |
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}}} // of namespace utility, yat, and theplu |